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EMBO Rep. 2008 Jul;9(7):662-9. doi: 10.1038/embor.2008.70. Epub 2008 May 2.

A transcription cofactor required for the heat-shock response.

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1
Laboratory of Cancer Biology, Medical Sciences Division, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.

Abstract

The Stress-responsive activator of p300 (Strap) is a transcription cofactor that has an important role in the control of DNA damage response through its ability to regulate p53 activity. Here, we report that Strap is inducible by heat shock and stimulates the transcription of heat-shock genes. A chromatin-associated complex involving heat-shock factor 1 (HSF1), Strap and the p300 coactivator assembles on the heat-shock protein 70 (hsp70) promoter, and Strap augments HSF1 binding and chromatin acetylation in Hsp genes, most probably through the p300 histone acetyltransferase. Cells depleted of Strap do not survive under heat-shock conditions. These results indicate that Strap is an essential cofactor that acts at the level of chromatin control to regulate heat-shock-responsive transcription.

PMID:
18451878
PMCID:
PMC2475325
DOI:
10.1038/embor.2008.70
[Indexed for MEDLINE]
Free PMC Article
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