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Curr Opin Neurol. 2008 Jun;21(3):255-60. doi: 10.1097/WCO.0b013e3282fd10cc.

The genetics of multiple sclerosis and its experimental models.

Author information

1
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. Tomas.Olsson@ki.se

Abstract

PURPOSE OF REVIEW:

We review the current thinking on the genetic aetiology of multiple sclerosis, new aspects of the influence of genes within the human leucocyte antigen (HLA) complex, how discrete non-HLA genes regulating multiple sclerosis start to be unequivocally demonstrated, and how knowledge from the genetics of experimental models of multiple sclerosis can be used.

RECENT FINDINGS:

Different alleles of the class II molecules display a hierarchy of risks including protective effects in multiple sclerosis. In addition, HLA class I genes are associated with the disease. Experimental multiple sclerosis models are regulated by many genes with small effects, more than about 100. Studies in humans suggest a similar situation. Indeed, the two genes unequivocally established, IL2RA and IL7RA, display a low odds ratio in the order of 1.3. We envisage that many more genes of this kind may be unravelled in the years to come.

SUMMARY:

There are hierarchies of influences from class II genes. Class I genes regulate disease as well. The unambiguous demonstration of non-HLA genes also suggests that many other genes impacting multiple sclerosis can be deciphered in the years to come. A complete knowledge of the most important of these may pave the way for more selective therapy and gene-environment studies.

PMID:
18451707
DOI:
10.1097/WCO.0b013e3282fd10cc
[Indexed for MEDLINE]

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