Cocrystallization of 2,2'-dithiodibenzoic acid with isonicotinohydrazide from methanol solution yields the 1:2 cocrystal 2,2'-dithiodibenzoic acid-isonicotinohydrazide (1/2), C(14)H(10)O(4)S(2) x 2 C(6)H(7)N(3)O. The component molecules are linked by intermolecular O-H...N, N-H...O, N-H...N and C-H...O hydrogen bonds into layers running parallel to the (010) plane, and these layers are further linked into a three-dimensional framework structure by means of weak aromatic pi-pi stacking interactions. As a potential cocrystallization agent, isonicotinohydrazide may be used for effective and versatile synthetic supramolecular strategies utilizing hydrogen bonding of specific molecular building blocks.