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Br J Psychiatry. 2008 May;192(5):333-7. doi: 10.1192/bjp.bp.107.041541.

Birth weight of infants after maternal exposure to typical and atypical antipsychotics: prospective comparison study.

Author information

1
University of Newcastle, Leazes Wing, Royal Victoria Infirmary, Newcastle upon Tyne, UK. R.H.McAllister-Williams@ncl.ac.uk

Erratum in

  • Br J Psychiatry. 2008 Jun;192(6):477.

Abstract

BACKGROUND:

The effects of in utero exposure to atypical antipsychotics on infant birth weight are unknown.

AIMS:

To determine whether atypical and typical antipsychotics differ in their effects on birth weight after maternal exposure during pregnancy.

METHOD:

Prospective data on gestational age and birth weight collected by the National Teratology Information Service for infants exposed to typical (n=45) and atypical (n=25) antipsychotics was compared with data for a reference group of infants (n=38).

RESULTS:

Infants exposed to atypical antipsychotics had a significantly higher incidence of large for gestational age (LGA) than both comparison groups and a mean birth weight significantly heavier than those exposed to typical antipsychotics. In contrast those exposed to typical antipsychotics had a significantly lower mean birth weight and a higher incidence of small for gestational age infants than the reference group.

CONCLUSIONS:

In utero exposure to atypical antipsychotic drugs may increase infant birth weight and risk of LGA.

Comment in

PMID:
18450655
DOI:
10.1192/bjp.bp.107.041541
[Indexed for MEDLINE]

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