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Curr Opin Cell Biol. 2008 Jun;20(3):294-302. doi: 10.1016/j.ceb.2008.03.006. Epub 2008 Apr 29.

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation.

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1
Department of Molecular Biology and Genetics, Cornell University, 465 Biotechnology Building, Ithaca, NY 14853, United States. wlk5@cornell.edu

Abstract

The regulation of gene expression requires a wide array of protein factors that can modulate chromatin structure, act at enhancers, function as transcriptional coregulators, or regulate insulator function. Poly(ADP-ribose) polymerase-1 (PARP-1), an abundant and ubiquitous nuclear enzyme that catalyzes the NAD(+)-dependent addition of ADP-ribose polymers on a variety of nuclear proteins, has been implicated in all of these functions. Recent biochemical, genomic, proteomic, and cell-based studies have highlighted the role of PARP-1 in each of these processes and provided new insights about the molecular mechanisms governing PARP-1-dependent regulation of gene expression. In addition, these studies have demonstrated how PARP-1 functions as an integral part of cellular signaling pathways that culminate in gene-regulatory outcomes.

PMID:
18450439
PMCID:
PMC2518631
DOI:
10.1016/j.ceb.2008.03.006
[Indexed for MEDLINE]
Free PMC Article
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