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Mol Cell Endocrinol. 2008 Jun 25;288(1-2):79-85. doi: 10.1016/j.mce.2008.03.001. Epub 2008 Mar 16.

Weighing up beta-cell mass in mice and humans: self-renewal, progenitors or stem cells?

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1
Centre for Human Development, Stem Cells & Regeneration, University of Southampton, Southampton, UK. N.A.Hanley@soton.ac.uk

Abstract

Understanding how beta-cells maintain themselves in the adult pancreas is important for prioritizing strategies aimed at ameliorating or ideally curing different forms of diabetes. There has been much debate over whether beta-cell proliferation, as a means of self-renewal, predominates over the existence and differentiation of a pancreatic stem cell or progenitor cell population. This article describes the two opposing positions based largely on research in laboratory rodents and its extrapolation to humans.

PMID:
18450368
DOI:
10.1016/j.mce.2008.03.001
[Indexed for MEDLINE]
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