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J Autism Dev Disord. 2008 Nov;38(10):1827-36. doi: 10.1007/s10803-008-0571-9. Epub 2008 May 1.

Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP study.

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1
Newcomen Centre, Guy's & St. Thomas' NHS Foundation Trust, London, SE1 9RT, UK. gillian.baird@gstt.nhs.uk

Abstract

We report rates of regression and associated findings in a population derived group of 255 children aged 9-14 years, participating in a prevalence study of autism spectrum disorders (ASD); 53 with narrowly defined autism, 105 with broader ASD and 97 with non-ASD neurodevelopmental problems, drawn from those with special educational needs within a population of 56,946 children. Language regression was reported in 30% with narrowly defined autism, 8% with broader ASD and less than 3% with developmental problems without ASD. A smaller group of children were identified who underwent a less clear setback. Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems.

PMID:
18449635
DOI:
10.1007/s10803-008-0571-9
[Indexed for MEDLINE]
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