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Ann N Y Acad Sci. 2008 Apr;1126:42-5. doi: 10.1196/annals.1433.063.

Receptor for advanced glycation end product expression in experimental diabetic retinopathy.

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5th Medical Clinic, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.


The advanced glycation end product (AGE)-receptor for AGE (RAGE) pathway is involved in the pathogenesis of diabetic microvascular damage. The special distribution of RAGE and its engagement has an impact on the development of diabetic retinopathy. In the present study, we used immunofluorescence and confocal laser microscopy to study RAGE expression with special emphasis on Müller glia in Sprague Dawley rats. RAGE expression was low in nondiabetic retinae and was found in ganglion cells and Müller cell end feet. In diabetic retinae, upregulated RAGE was predominantly expressed in retinal glia. Since Müller cells are important in the regulation of important features of early retinal vascular damage, such as vascular permeability, homeostasis, and response to stress, RAGE appears to be a central modulator in diabetic retinopathy.

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