Format

Send to

Choose Destination
See comment in PubMed Commons below
Joint Bone Spine. 2008 Jul;75(4):383-7. doi: 10.1016/j.jbspin.2007.11.003. Epub 2008 Apr 29.

The genetics of intervertebral disc degeneration. Familial predisposition and heritability estimation.

Author information

1
Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, 650 Albany Street, X200, Boston, MA 02118, USA. leonid@bu.edu

Abstract

OBJECTIVES:

To review current knowledge on heritability of intervertebral disc degeneration (IDD). IDD can contribute to the development of low back pain and acute lumbar radiculopathy. Dramatic change in the current view of risk factors for IDD from one where age and mechanical factors were paramount to the current theory that genetic risk factors are predominant, we thought that it is important to review the studies of the genetic influences on IDD beginning from familial aggregation and heritability estimation and finishing with specific studies of genes associated with IDD.

METHODS:

A literature-based narrative review of English language medical literature.

RESULTS AND CONCLUSIONS:

Prior research has demonstrated the existence of familial predisposition to IDD with generally high heritabilities that range from 34% to 61% in different spine locations. Segregation analysis shows that the mode of inheritance is complex with multiple factors and multiple genes likely involved in intergenerational transmission.

PMID:
18448379
DOI:
10.1016/j.jbspin.2007.11.003
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center