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PLoS One. 2008 Apr 30;3(4):e2029. doi: 10.1371/journal.pone.0002029.

The mych gene is required for neural crest survival during zebrafish development.

Author information

1
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America. hongsk@mail.nih.gov

Abstract

BACKGROUND:

Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes.

PRINCIPAL FINDINGS:

We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain.

SIGNIFICANCE:

Mych is a novel factor required for neural crest cell survival in zebrafish.

PMID:
18446220
PMCID:
PMC2323570
DOI:
10.1371/journal.pone.0002029
[Indexed for MEDLINE]
Free PMC Article

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