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Nat Rev Neurosci. 2008 Jun;9(6):417-22. doi: 10.1038/nrn2391. Epub 2008 Apr 30.

A technicolour approach to the connectome.

Author information

1
Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA. jeff@mcb.harvard.edu

Abstract

A central aim of neuroscience is to map neural circuits, in order to learn how they account for mental activities and behaviours and how alterations in them lead to neurological and psychiatric disorders. However, the methods that are currently available for visualizing circuits have severe limitations that make it extremely difficult to extract precise wiring diagrams from histological images. Here we review recent advances in this area, along with some of the opportunities that these advances present and the obstacles that remain.

PMID:
18446160
PMCID:
PMC2577038
DOI:
10.1038/nrn2391
[Indexed for MEDLINE]
Free PMC Article

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