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Sci Signal. 2008 Apr 29;1(17):pe17. doi: 10.1126/stke.117pe17.

Notch signaling in osteoblasts.

Author information

  • 1Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA. ecanalis@stfranciscare.org

Abstract

Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.

PMID:
18445833
DOI:
10.1126/stke.117pe17
[PubMed - indexed for MEDLINE]
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