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J Mol Med (Berl). 2008 Jun;86(6):637-41. doi: 10.1007/s00109-008-0344-0. Epub 2008 Apr 29.

Genetics of the human renin angiotensin system.

Author information

1
INSERM U772, Coll├Ęge de France, 11 place Marcelin Berthelot, Paris, France. xavier.jeunemaitre@college-de-France.fr

Abstract

The genes coding for the renin angiotensin system have been extensively studied. During the last 15 years, informative markers and functional polymorphisms have been identified, and numerous linkage and association studies have been performed in cardiovascular diseases, especially human hypertension. This mini-review aims to summarize the main findings observed for each component of this enzymatic cascade taken alone or in combination, with an emphasis on the most recent or innovative studies.

PMID:
18443750
DOI:
10.1007/s00109-008-0344-0
[Indexed for MEDLINE]

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