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Chem Soc Rev. 2008 May;37(5):1052-60. doi: 10.1039/b708459p. Epub 2008 Mar 20.

SERS--a single-molecule and nanoscale tool for bioanalytics.

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1
Harvard University Medical School, Wellman Center for Photomedicine, Boston, MA 02114, USA. jkneipp@janina-kneipp.de

Abstract

Surface enhanced Raman scattering (SERS) at extremely high enhancement level turns the weak inelastic scattering effect of photons on vibrational quantum states into a structurally sensitive single-molecule and nanoscale probe. The effect opens up exciting opportunities for applications of vibrational spectroscopy in biology. The concept of SERS can be extended to two-photon excitation by exploiting surface enhanced hyper-Raman scattering (SEHRS). This critical review introduces the physics behind single-molecule SERS and discusses the capabilities of the effect in bioanalytics (100 references).

PMID:
18443689
DOI:
10.1039/b708459p
[Indexed for MEDLINE]
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