Send to

Choose Destination
See comment in PubMed Commons below
Theor Popul Biol. 2008 Jun;73(4):529-42. doi: 10.1016/j.tpb.2008.03.002. Epub 2008 Mar 22.

Multilocus models in the infinite island model of population structure.

Author information

  • 1Station Biologique de Roscoff, CNRS, Adaptation et Diversit√© en Milieu Marin, Place Georges Teissier, BP 74, 29682 Roscoff Cedex, France.


Different methods have been developed to consider the effects of statistical associations among genes that arise in population genetics models: kin selection models deal with associations among genes present in different interacting individuals, while multilocus models deal with associations among genes at different loci. It was pointed out recently that these two types of models are very similar in essence. In this paper, we present a method to construct multilocus models in the infinite island model of population structure (where deme size may be arbitrarily small). This method allows one to compute recursions on allele frequencies, and different types of genetic associations (including associations between different individuals from the same deme), and incorporates selection. Recursions can be simplified using quasi-equilibrium approximations; however, we show that quasi-equilibrium calculations for associations that are different from zero under neutrality must include a term that has not been previously considered. The method is illustrated using simple examples.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center