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Biochim Biophys Acta. 2008 May;1779(5):295-305. doi: 10.1016/j.bbagrm.2008.04.001. Epub 2008 Apr 8.

Transcriptional regulation of human small nuclear RNA genes.

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  • 1Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA.

Abstract

The products of human snRNA genes have been frequently described as performing housekeeping functions and their synthesis refractory to regulation. However, recent studies have emphasized that snRNA and other related non-coding RNA molecules control multiple facets of the central dogma, and their regulated expression is critical to cellular homeostasis during normal growth and in response to stress. Human snRNA genes contain compact and yet powerful promoters that are recognized by increasingly well-characterized transcription factors, thus providing a premier model system to study gene regulation. This review summarizes many recent advances deciphering the mechanism by which the transcription of human snRNA and related genes are regulated.

PMID:
18442490
PMCID:
PMC2684849
DOI:
10.1016/j.bbagrm.2008.04.001
[PubMed - indexed for MEDLINE]
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