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J Nat Prod. 2008 Jun;71(6):1000-4. doi: 10.1021/np8000464. Epub 2008 Apr 29.

Antiproliferative oleanane saponins from Meryta denhamii.

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1
Dipartimento di Scienze Farmaceutiche, Universitaàdi Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.

Abstract

Eight new oleanane saponins (1- 8) together with four know saponins (9-12) were isolated from the aerial parts of Meryta denhamii. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, ROESY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis. The antiproliferative activity of all compounds was evaluated using three murine and human cancer cell lines: J774.A1, HEK-293, and WEHI-164.

PMID:
18442289
DOI:
10.1021/np8000464
[Indexed for MEDLINE]
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