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Circ J. 2008 May;72(5):850-2.

Infliximab treatment for refractory Kawasaki disease with coronary artery aneurysm.

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Department of Pediatrics, Kochi National Hospital, Kochi, Japan.

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  • Circ J. 2008 Jul;72(7):1212.


Tumor necrosis factor-alpha (TNF-alpha) is considered to be 1 of the factors that induce vasculitis, including coronary artery aneurysm (CA), in Kawasaki disease (KD), because the blood concentration of TNF-alpha is higher in patients with CA compared with those without. Therefore, an anti-TNF-alphaagent (infliximab) was administered to a 1-month-old girl with refractory KD complicated by CA and subsequently, the CA improved and KD was controlled without complications 20 months after the onset.

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