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Comput Biol Chem. 2008 Jun;32(3):215-7. doi: 10.1016/j.compbiolchem.2008.02.006. Epub 2008 Feb 26.

MASIC: a software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC-MS(/MS) features.

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Pacific Northwest National Laboratory, Richland, WA 99354, USA.


Quantitative analysis of liquid chromatography (LC)-mass spectrometry (MS) and tandem mass spectrometry (MS/MS) data is essential to many proteomics studies. We have developed MASIC(2) to accurately measure peptide abundances and LC elution times in LC-MS/MS analyses. This software program uses an efficient processing algorithm to quickly generate mass specific selected ion chromatograms from a dataset and provides an interactive browser that allows users to examine individual chromatograms with a variety of options.

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