Format

Send to

Choose Destination
Curr Opin Cell Biol. 2008 Jun;20(3):316-25. doi: 10.1016/j.ceb.2008.03.004. Epub 2008 Apr 25.

Mechanisms involved in the regulation of histone lysine demethylases.

Author information

1
Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, United States. fei_lan@student.hms.harvard.edu

Abstract

Since the first histone lysine demethylase KDM1 (LSD1) was discovered in 2004, a great number of histone demethylases have been recognized and shown to play important roles in gene expression, as well as cellular differentiation and animal development. The chemical mechanisms and substrate specificities have already been extensively discussed elsewhere. This review focuses primarily on regulatory mechanisms that modulate demethylase recruitment and activity.

PMID:
18440794
PMCID:
PMC2674377
DOI:
10.1016/j.ceb.2008.03.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center