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Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):95-102. doi: 10.1016/j.ejogrb.2008.02.023. Epub 2008 Apr 28.

Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells.

Author information

1
Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University, Renmin South Road, Chengdu 610041, People's Republic of China.

Abstract

OBJECTIVES:

To observe the anti-tumor activities of honokiol on human ovarian tumor in vitro and in vivo.

STUDY DESIGN:

Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed.

RESULTS:

Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth.

CONCLUSIONS:

Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment.

PMID:
18440692
DOI:
10.1016/j.ejogrb.2008.02.023
[Indexed for MEDLINE]

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