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Fertil Steril. 2008 Dec;90(6):2144-51. doi: 10.1016/j.fertnstert.2007.10.035. Epub 2008 Apr 28.

Estimation of chromosomal imbalances in preimplantation embryos from preimplantation genetic diagnosis cycles of reciprocal translocations with or without acrocentric chromosomes.

Author information

1
Laboratory of Reproductive Biology and Infertility, Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine, Seoul, South Korea.

Abstract

OBJECTIVE:

To estimate chromosomal imbalances in preimplantation embryos from reciprocal translocation carriers with or without acrocentric chromosomes (Acro-Ch) 13, 14, 15, 21, and 22 in preimplantation genetic diagnosis (PGD) cycles.

DESIGN:

Fluorescence in situ hybridization was applied to PGD cycles for reciprocal translocation carriers.

SETTING:

University-based centers for reproductive medicine.

PATIENT(S):

Ten and 24 patients of reciprocal translocation with and without Acro-Ch, respectively.

INTERVENTION(S):

Fluorescence in situ hybridization in biopsied blastomeres.

MAIN OUTCOME MEASURE(S):

Estimation of meiotic segregation mode in embryos from translocation carriers.

RESULT(S):

The proportion of alternative segregation for normal or balanced chromosome contents in preimplantation embryos from PGD cycles in reciprocal translocations without Acro-Ch was significantly higher than that with Acro-Ch (26.0% vs. 14.6%). The proportion of interchange trisomy in 3:1 segregation was significantly lower in reciprocal translocations without Acro-Ch than that with Acro-Ch (4.3% vs. 9.5%).

CONCLUSION(S):

This is the first report that the incidence of alternative segregation producing normal or balanced embryos was relatively low in reciprocal translocations associated with Acro-Ch. Our data may be useful to predict the possibility of normal or balanced embryos and to counsel with reciprocal translocation carriers for PGD-fluorescence in situ hybridization cycles.

[Indexed for MEDLINE]

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