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Carbohydr Res. 2008 Jul 21;343(10-11):1718-29. doi: 10.1016/j.carres.2008.03.033. Epub 2008 Apr 4.

Synthesis and biological evaluation of sperm CD52 GPI anchor and related derivatives as binding receptors of pore-forming CAMP factor.

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Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.

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  • Carbohydr Res. 2009 May 12;344(7):952.


Sperm CD52 GPI anchor and its derivatives containing different carbohydrate chains were prepared in a highly convergent fashion starting from the same properly protected phospholipidated pseudodisaccharide. Coupling this common key intermediate to various oligosaccharyl donors quickly afforded the framework of the synthetic targets, which was followed by global deprotection to furnish the desired structures. Preliminary studies on the biological properties of the synthetic GPI derivatives indicated that both the intact GPI anchor and the free phospholipidated pseudodisaccharide interacted strongly with CAMP factor, a pore-forming bacterial toxin.

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