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Schmerz. 2008 Oct;22(5):571-4. doi: 10.1007/s00482-008-0660-x.

[Topical application of morphine and buprenorphine gel has no effect in the sunburn model].

[Article in German]

Author information

1
Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin und Schmerztherapie, Medizinische Universität Wien, Währinger Gürtel 18-20, A-1090 Wien, Osterreich.

Abstract

BACKGROUND:

The aim of this placebo-controlled double-blinded cross-over study was to investigate the antihyperalgesic effect of topical morphine and buprenorphine in the sunburn pain model.

MATERIAL AND METHODS:

The study was designed as a double-blind, placebo-controlled cross-over trial, separated into 2 parts each with 16 volunteers. In part A morphine dissolved in Ultrabas-ultrasic ointment at 3 concentrations (0.1, 0.2, 0.4%) and placebo ointment were applied to 4 UVB-induced erythemas on the thighs. In part B buprenorphine at 3 concentrations (0.01, 0.02 and 0.1%) and placebo dissolved in a gel for transcutaneous application, was applied to 4 erythemas on the thighs. Thermal and mechanical hyperalgesia were assessed in the respective erythema by standardized quantitative sensory testing and opioids were compared to the placebo.

RESULTS:

Neither morphine nor buprenorphine showed any significant reduction of hyperalgesia in comparison to the placebo.

CONCLUSION:

The topical application of opioids in this form has no effect on inflamed skin.

PMID:
18438689
DOI:
10.1007/s00482-008-0660-x
[Indexed for MEDLINE]
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