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Nat Genet. 2008 Jun;40(6):713-5. doi: 10.1038/ng.148. Epub 2008 Apr 27.

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.

Author information

1
Institute for Clinical Molecular Biology, Christian-Albrechts-University, D-24105 Kiel, Germany.

Abstract

Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.

PMID:
18438405
DOI:
10.1038/ng.148
[Indexed for MEDLINE]

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