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Parasitol Res. 2008 Jul;103(2):341-4. doi: 10.1007/s00436-008-0977-5. Epub 2008 Apr 25.

Antiplasmodial activity of sesquiterpene lactone from Carpesium rosulatum in mice.

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Department of Applied Life science, Kon Kuk University, Seoul, 143-701, South Korea.


In the previous work, methanol extracts of Carpesium rosulatum (Compositae) were found to have high antiplasmodial activity against Plasmodium falciparum in vitro, this activity being largely attributable to a ineupatorolides A (I-A). In the present study, encouragingly, I-A was also found to have potential antimalarial activity in vivo when tested against Plasmodium berghei in mice. I-A (2, 5, 10 mg kg(-1) day(-1)) exhibited a significant blood schizontocidal activity in 4-day early infection, repository evaluation, and in established infection with a significant mean survival time comparable to that of the standard drug, chloroquine (5 mg kg(-1) day(-1)). The I-A possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.

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