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FEBS Lett. 2008 May 14;582(11):1625-8. doi: 10.1016/j.febslet.2008.04.022. Epub 2008 Apr 22.

The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake.

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Biology Department Area 9, University of York, York YO10 5DD, United Kingdom.


We studied the effect of loss of function in the NIP subfamily II in Arabidopsis thaliana to assess their potential role(s) in arsenite (AsIII) uptake. Loss of function in AtNIP7;1 led to increased plant tolerance to AsIII and reduced total As in planta. AtNIP7;1 expression in various yeast backgrounds increased AsIII sensitivity. In the acr3Delta yeast genotype, AtNIP7;1 caused a moderate increase in AsV tolerance. Short-term As uptake in fsp1Delta expressing AtNIP7;1 was significantly larger than that in the empty vector control. The data suggest that AtNIP7;1 can mediate AsIII transport and contributes to AsIII uptake in plants.

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