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Photochem Photobiol. 2008 May-Jun;84(3):539-49. doi: 10.1111/j.1751-1097.2007.00226.x.

The protective role of melanin against UV damage in human skin.

Author information

1
Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Abstract

Human skin is repeatedly exposed to UVR that influences the function and survival of many cell types and is regarded as the main causative factor in the induction of skin cancer. It has been traditionally believed that skin pigmentation is the most important photoprotective factor, as melanin, besides functioning as a broadband UV absorbent, has antioxidant and radical scavenging properties. Besides, many epidemiological studies have shown a lower incidence for skin cancer in individuals with darker skin compared to those with fair skin. Skin pigmentation is of great cultural and cosmetic importance, yet the role of melanin in photoprotection is still controversial. This article outlines the major acute and chronic effects of UVR on human skin, the properties of melanin, the regulation of pigmentation and its effect on skin cancer prevention.

PMID:
18435612
PMCID:
PMC2671032
DOI:
10.1111/j.1751-1097.2007.00226.x
[Indexed for MEDLINE]
Free PMC Article

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