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J Virol. 2008 Jul;82(13):6209-17. doi: 10.1128/JVI.00251-08. Epub 2008 Apr 23.

Genetic analysis of Israel acute paralysis virus: distinct clusters are circulating in the United States.

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1
Center for Infection and Immunity, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 1801, New York, NY 10032, USA. gp2050@columbia.edu

Abstract

Israel acute paralysis virus (IAPV) is associated with colony collapse disorder of honey bees. Nonetheless, its role in the pathogenesis of the disorder and its geographic distribution are unclear. Here, we report phylogenetic analysis of IAPV obtained from bees in the United States, Canada, Australia, and Israel and the establishment of diagnostic real-time PCR assays for IAPV detection. Our data indicate the existence of at least three distinct IAPV lineages, two of them circulating in the United States. Analysis of representatives from each proposed lineage suggested the possibility of recombination events and revealed differences in coding sequences that may have implications for virulence.

PMID:
18434396
PMCID:
PMC2447087
DOI:
10.1128/JVI.00251-08
[Indexed for MEDLINE]
Free PMC Article

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