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Curr Opin Immunol. 2008 Apr;20(2):149-57. doi: 10.1016/j.coi.2008.03.014. Epub 2008 Apr 21.

Peripheral B cell subsets.

Author information

1
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. dallman@mail.med.upenn.edu

Abstract

Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.

PMID:
18434123
PMCID:
PMC2532490
DOI:
10.1016/j.coi.2008.03.014
[Indexed for MEDLINE]
Free PMC Article

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