Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia

Ying Wei; Chao-mei Ma; De-yuan Chen; Masao Hattori

doi:10.1016/j.phytochem.2008.03.004

Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia

Phytochemistry. 2008 Jun;69(9):1875-9. doi: 10.1016/j.phytochem.2008.03.004. Epub 2008 Apr 21.

Authors

Ying Wei¹, Chao-mei Ma, De-yuan Chen, Masao Hattori

Affiliation

¹ Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

PMID: 18433808
DOI: 10.1016/j.phytochem.2008.03.004

Abstract

Three triterpenoids, 16beta-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (1), 3beta,21beta,24-trihydroxy-30-noroleana-12,20(29)-dien-28-oic acid (2) and 16beta-hydroxylupane-1,20(29)-dien-3-one (3), along with eleven known triterpenes were isolated from stems of Stauntonia obovatifoliola Hayata subsp. intermedia (Y.C. Wu) T. Chen. Their structures were determined by analysis of HR-EI/FAB-MS and 1D and 2D NMR spectroscopic data and comparison with those in the literature. Ten of the compounds showed inhibitory activity against HIV-1 protease.

MeSH terms

Ferns / chemistry*
HIV Protease Inhibitors / chemistry*
HIV Protease Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Triterpenes / chemistry*
Triterpenes / pharmacology*

Substances

HIV Protease Inhibitors
Triterpenes