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Nat Neurosci. 2008 Jun;11(6):631-3. doi: 10.1038/nn.2120. Epub 2008 Apr 23.

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri.

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1
Department of Bioengineering and Psychiatry, W083 Clark Center, 318 Campus Drive, Stanford University, Stanford, California 94305, USA.

Abstract

The introduction of two microbial opsin-based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type-specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted approximately 70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.

PMID:
18432196
PMCID:
PMC2692303
DOI:
10.1038/nn.2120
[Indexed for MEDLINE]
Free PMC Article
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