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PLoS One. 2008 Apr 23;3(4):e2012. doi: 10.1371/journal.pone.0002012.

Infection of cultured human endothelial cells by Legionella pneumophila.

Author information

1
Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America.

Abstract

Legionella pneumophila is a gram-negative pathogen that causes a severe pneumonia known as Legionnaires' disease. Here, we demonstrate for the first time that L. pneumophila infects and grows within cultured human endothelial cells. Endothelial infection may contribute to lung damage observed during Legionnaires' disease and to systemic spread of this organism.

PMID:
18431493
PMCID:
PMC2292252
DOI:
10.1371/journal.pone.0002012
[Indexed for MEDLINE]
Free PMC Article

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