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Nat Rev Mol Cell Biol. 2008 May;9(5):355-66. doi: 10.1038/nrm2388.

Mechanisms of asymmetric cell division: flies and worms pave the way.

Author information

1
Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology (EPFL), School of Life Sciences, Lausanne, Switzerland. Pierre.Gonczy@epfl.ch

Abstract

Asymmetric cell division is fundamental for generating diversity in multicellular organisms. The mechanisms that govern asymmetric cell division are increasingly well understood, owing notably to studies that were conducted in Drosophila melanogaster and Caenorhabditis elegans. Lessons learned from these two model organisms also apply to cells that divide asymmetrically in other metazoans, such as self-renewing stem cells in mammals.

PMID:
18431399
DOI:
10.1038/nrm2388
[Indexed for MEDLINE]

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