Format

Send to

Choose Destination
See comment in PubMed Commons below
J Leukoc Biol. 2008 Oct;84(4):958-64. doi: 10.1189/jlb.1107775. Epub 2008 Apr 22.

Synthetic oligonucleotides as modulators of inflammation.

Author information

1
National Cancer Institute, Frederick, MD 21702, USA. klinmand@mail.nih.gov

Abstract

Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and plasmacytoid dendritic cells, promote the production of Th1 and proinflammatory cytokines, and trigger the maturation/activation of professional APC. CpG ODN are finding use in the treatment of cancer, allergy, and infection. In contrast, ODN containing multiple TTAGGG motifs mimic the immunosuppressive activity of self-DNA, down-regulating the production of proinflammatory and Th1 cytokines. Preclinical studies suggest that "suppressive" ODN may slow or prevent diseases characterized by pathologic immune stimulation, including autoimmunity and septic shock. Extensive studies in animal models suggest that the therapeutic value of CpG and TTAGGG ODN may be optimized by early administration.

PMID:
18430787
PMCID:
PMC2538593
DOI:
10.1189/jlb.1107775
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center