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Curr Protoc Hum Genet. 2004 May;Chapter 15:Unit 15.5. doi: 10.1002/0471142905.hg1505s40.

Use of chicken models for the analysis of human disease.

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  • 1Michigan State University, East Lansing, Michigan, USA.

Abstract

The chicken has been a valuable model organism for genetic analysis since early in the last century. This unit provides an overview of the primary strategic approaches through which the chicken is used as a model for human genetics and disease. These approaches are reviewed with key advantages and disadvantages noted for each. In addition, the chicken offers a model system for several human inherited diseases, both single gene-based and complex traits. This unit briefly describes two such models as examples: autoimmune pathology causing Hashimoto's thyroiditis and sex-linked dwarfism.

PMID:
18428358
DOI:
10.1002/0471142905.hg1505s40
[PubMed - indexed for MEDLINE]
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