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Lab Invest. 2008 Jun;88(6):569-78. doi: 10.1038/labinvest.2008.32. Epub 2008 Apr 21.

Everything you wanted to know about small RNA but were afraid to ask.

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Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305-2297, USA.


MicroRNAs are a class of recently discovered small RNA molecules that regulate other genes in the human genome. Studies in human cells and model organisms have begun to reveal the mechanisms of microRNA activity, and the wide range of normal physiological functions they influence. Their alteration in pathologic states from cancer to cardiovascular disease is also increasingly clear. A review of current evidence for the role of these molecules in human health and disease will be helpful to pathologists and medical researchers as the fascinating story of these small regulators continues to unfold.

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