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Cell Mol Life Sci. 2008 Jun;65(11):1706-15. doi: 10.1007/s00018-008-7584-6.

Heparanase involvement in physiology and disease.

Author information

1
Department of Oncology, Shaare Zedek Medical Center, Jerusalem, Israel. nicola.nasser@gmail.com

Abstract

Heparanase is an endoglycosidase that degrades heparan sulfate on the cell surface and extracellular matrix. The physiological functions of heparanase include heparan sulfate turnover, embryo development, hair growth, and wound healing. Heparanase is implicated in a variety of pathologies, such as tumor growth, angiogenesis, metastasis, inflammation, and glomerular diseases. Heparanase overexpression in a variety of malignant tumors suggests that it could be a target for anti-cancer therapy.

PMID:
18425416
DOI:
10.1007/s00018-008-7584-6
[Indexed for MEDLINE]

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