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J Magn Reson. 2008 Jul;193(1):139-46. doi: 10.1016/j.jmr.2008.03.012. Epub 2008 Mar 23.

Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products.

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Department of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont., Canada M4N 3M5.


Dynamic nuclear polarization and dissolution of a (13)C-labeled substrate enables the dynamic imaging of cellular metabolism. Spectroscopic information is typically acquired, making the acquisition of dynamic volumetric data a challenge. To enable rapid volumetric imaging, a spectral-spatial excitation pulse was designed to excite a single line of the carbon spectrum. With only a single resonance present in the signal, an echo-planar readout trajectory could be used to resolve spatial information, giving full volume coverage of 32 x 32 x 16 voxels every 3.5s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer.

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