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Bioorg Med Chem Lett. 2008 May 1;18(9):2820-4. doi: 10.1016/j.bmcl.2008.04.003. Epub 2008 Apr 4.

New tetrazole-based selective anandamide uptake inhibitors.

Author information

1
Dipartimento di Studi Farmaceutici, Sapienza Università di Roma, piazzale Aldo Moro 5, 00185 Roma, Italy. giorgio.ortar@uniroma1.it

Abstract

A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC(50)=2.3-5.1microM) and selectively over other proteins involved in endocannabinoid action and metabolism.

PMID:
18424134
DOI:
10.1016/j.bmcl.2008.04.003
[Indexed for MEDLINE]

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