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Exp Cell Res. 2008 Jun 10;314(9):1909-17. doi: 10.1016/j.yexcr.2008.02.023. Epub 2008 Mar 12.

Aging by epigenetics--a consequence of chromatin damage?

Author information

1
Brown University, Division of Biology and Medicine, Laboratories for Molecular Medicine, 70 Ship Street, Providence, RI 02903, USA. john_sedivy@brown.edu

Abstract

Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.

PMID:
18423606
PMCID:
PMC2464300
DOI:
10.1016/j.yexcr.2008.02.023
[Indexed for MEDLINE]
Free PMC Article
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