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Cell. 2008 Apr 18;133(2):280-91. doi: 10.1016/j.cell.2008.02.032.

Meiosis I is established through division-specific translational control of a cyclin.

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1
Center for Cancer Research, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.

Abstract

In budding yeast, key meiotic events such as DNA replication, recombination, and the meiotic divisions are controlled by Clb cyclin-dependent kinases (Clb-CDKs). Using a novel synchronization procedure, we have characterized the activity of these Clb-CDKs and observed a surprising diversity in their regulation during the meiotic divisions. Clb1-CDK activity is restricted to meiosis I, and Clb3-CDK activity to meiosis II, through 5'UTR-mediated translational control of its transcript. The analysis of cells inappropriately producing Clb3-CDKs during meiosis I furthermore defines Clb3 as an inhibitor of the meiosis I chromosome segregation program. Our results demonstrate an essential role for Clb-CDK regulation in establishing the meiotic chromosome segregation pattern.

PMID:
18423199
PMCID:
PMC2396536
DOI:
10.1016/j.cell.2008.02.032
[Indexed for MEDLINE]
Free PMC Article
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