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Cell. 2008 Apr 18;133(2):204-5. doi: 10.1016/j.cell.2008.04.005.

Rethinking pseudokinases.

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1
Department of Chemistry, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92014-6054, USA.

Abstract

Pseudokinases lack conservation of one or more of the catalytic residues in the kinase core and as a consequence are typically thought to be catalytically inactive. New work by Mukherjee et al. (2008) challenges this assumption. They show that the pseudokinase domain of CASK (Ca2+/calmodulin activated serine-threonine kinase) adopts an active conformation and displays catalytic activity in vivo.

PMID:
18423189
DOI:
10.1016/j.cell.2008.04.005
[Indexed for MEDLINE]
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