Format

Send to

Choose Destination
See comment in PubMed Commons below
FEMS Microbiol Rev. 2008 Jul;32(4):627-53. doi: 10.1111/j.1574-6976.2008.00114.x. Epub 2008 Apr 16.

Structure and genetics of Shigella O antigens.

Author information

  • 1TEDA School of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin, China.

Erratum in

  • FEMS Microbiol Rev. 2010 Jul;34(4):606.

Abstract

This review covers the O antigens of the 46 serotypes of Shigella, but those of most Shigella flexneri are variants of one basic structure, leaving 34 Shigella distinct O antigens to review, together with their gene clusters. Several of the structures and gene clusters are reported for the first time and this is the first such group for which structures and DNA sequences have been determined for all O antigens. Shigella strains are in effect Escherichia coli with a specific mode of pathogenicity, and 18 of the 34 O antigens are also found in traditional E. coli. Three are very similar to E. coli O antigens and 13 are unique to Shigella strains. The O antigen of Shigella sonnei is quite atypical for E. coli and is thought to have transferred from Plesiomonas. The other 12 O antigens unique to Shigella strains have structures that are typical of E. coli, but there are considerably more anomalies in their gene clusters, probably reflecting recent modification of the structures. Having the complete set of structures and genes opens the way for experimental studies on the role of this diversity in pathogenicity.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for Wiley
    Loading ...
    Support Center