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Neurobiol Aging. 2010 Jan;31(1):114-7. doi: 10.1016/j.neurobiolaging.2008.03.008. Epub 2008 Apr 16.

PITX3 polymorphism is associated with early onset Parkinson's disease.

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Department of Pharmacology, The Sahlgrenska Academy at the University of Gothenburg, P.O. Box 431, S 405 30 Göteborg, Sweden.


PITX3 is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons, the gene of which is disrupted in a putative mouse model for Parkinson's disease (PD). The A-allele of a HapMap tagging SNP (rs4919621) that was genotyped in a population of 361 PD patients, 69 of which had early onset, and in 333 controls, was significantly more common in PD patients with an early age of onset when compared either to controls (p=0.002) or to PD patients with late onset (p=0.001). In contrast, a previous finding suggesting a SNP (rs3758549) in the putative promoter region of the PITX3 gene to be associated with PD could not be replicated.

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