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Diagn Cytopathol. 2008 May;36(5):338-40. doi: 10.1002/dc.20805.

Koilocytes in urinary cytology in a patient with kidney transplant.

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Department of Pathology, Superiora Sor MarĂ­a Ludovica Children's Hospital, 1900 La Plata, Argentina.


We are reporting the case of a 17-year-old girl with kidney transplant under immunosuppressive treatment. Evidences of transplant malfunction led to urinary cytology to rule out BKV infection. The smears showed the presence of koilocytes. Gynecologic examination revealed numerous condylomatous lesions in the vulva, vagina, and cervix. PAP smears showed cells with moderate to severe koilocytic dysplasia. PCR performed on material retrieved from both the smears showed HPV18 DNA sequences. Koilocytes have rarely been documented in urinary cytologic examination. Since post-transplant immunosuppressed patients are prone to develop florid and extensive HPV infections, urinary cytology may prove useful for routine search of cells with this virus cytopathic effect.

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