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EMBO J. 2008 May 21;27(10):1481-90. doi: 10.1038/emboj.2008.76. Epub 2008 Apr 17.

Hzf regulates adipogenesis through translational control of C/EBPalpha.

Author information

1
Department of Mechanism of Aging, National Institute for Longevity Sciences, Aichi, Japan.

Abstract

Adipocyte differentiation requires a well-defined programme of gene expression in which the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein) has a central function. Here, we show that Hzf (haematopoietic zinc-finger), a previously identified p53 transcriptional target, regulates C/EBPalpha expression. Hzf is induced during differentiation of preadipocyte cell lines, and its suppression by short hairpin RNA disrupts adipogenesis. In Hzf's absence, expression of C/EBPalpha is severely impaired because of reduced translation of its mRNA. Hzf physically interacts with the 3' untranslated region of C/EBPalpha mRNA to enhance its translation. Taken together, these findings underscore a critical role of Hzf in the adipogenesis regulatory cascade.

PMID:
18418387
PMCID:
PMC2396393
DOI:
10.1038/emboj.2008.76
[Indexed for MEDLINE]
Free PMC Article

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