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J Clin Microbiol. 2008 Jun;46(6):2083-7. doi: 10.1128/JCM.00611-08. Epub 2008 Apr 16.

Rapid differentiation of methicillin-susceptible Staphylococcus aureus from methicillin-resistant S. aureus and MIC determinations by isothermal microcalorimetry.

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1
Laboratory for Orthopaedic Biomechanics, Clinical Morphology & Biomedical Engineering, University of Basel Faculty of Medicine, Basel, Switzerland.

Abstract

In this study, the use of isothermal microcalorimetry (IMC) for differentiation between methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) and MIC determination was evaluated. It was possible to differentiate between MRSA and MSSA within 4 h, whereas the standard method required 24 h. The MICs of cefoxitin were successfully determined for MRSA and MSSA by using IMC.

PMID:
18417657
PMCID:
PMC2446841
DOI:
10.1128/JCM.00611-08
[Indexed for MEDLINE]
Free PMC Article
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