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Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1179-85. doi: 10.1161/ATVBAHA.108.165886. Epub 2008 Apr 16.

Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004.

Author information

1
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA. mmelamed@aecom.yu.edu

Abstract

OBJECTIVE:

The purpose of this study was to determine the association between 25-hydroxyvitamin D (25(OH)D) levels and the prevalence of peripheral arterial disease (PAD) in the general United States population.

METHODS AND RESULTS:

We analyzed data from 4839 participants of the National Health and Nutrition Examination Survey 2001 to 2004 to evaluate the relationship between 25(OH)D and PAD (defined as an ankle-brachial index < 0.9). Across quartiles of 25(OH)D, from lowest to highest, the prevalence of PAD was 8.1%, 5.4%, 4.9%, and 3.7% (P trend < 0.001). After multivariable adjustment for demographics, comorbidities, physical activity level, and laboratory measures, the prevalence ratio of PAD for the lowest, compared to the highest, 25(OH)D quartile (< 17.8 and > or = 29.2 ng/mL, respectively) was 1.80 (95% confidence interval: 1.19, 2.74). For each 10 ng/mL lower 25(OH)D level, the multivariable-adjusted prevalence ratio of PAD was 1.35 (95% confidence interval: 1.15, 1.59).

CONCLUSIONS:

Low serum 25(OH)D levels are associated with a higher prevalence of PAD. Several mechanisms have been invoked in the literature to support a potential antiatherosclerotic activity of vitamin D. Prospective cohort and mechanistic studies should be designed to confirm this association.

PMID:
18417640
PMCID:
PMC2705139
DOI:
10.1161/ATVBAHA.108.165886
[Indexed for MEDLINE]
Free PMC Article
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