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Vaccine. 2008 May 12;26(20):2490-502. doi: 10.1016/j.vaccine.2008.03.008. Epub 2008 Mar 31.

Development of a travelers' diarrhea vaccine for the military: how much is an ounce of prevention really worth?

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Uniformed Services University of the Health Sciences, Bethesda, MD, USA.


Infectious diarrhea is one of the many threats to the deployed military, and given limited resources, a decision to pursue a vaccine acquisition strategy should be based on best evidence that weighs costs and benefits compared to alternatives. An economic model was developed to estimate the marginal cost to avert a duty day lost due to diarrhea for a vaccine acquisition strategy compared to current clinical management, for both multiplex and pathogen-specific vaccines. Vaccines against Campylobacter and enterotoxigenic Escherichia coli appeared to be more favorable than a Shigella vaccine. This model provides an evidence-based decision tool to support prioritization in vaccine development.

[Indexed for MEDLINE]

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